J. Shimizu 1, J. Kubota 1, T. Fukuda 2, A. Sasaki 3, T. Azuma 3, K. Sasaki 4, K. Shimizu 5, T. Oishi 6, S. Umemura 7, H. Furuhata 1
1 Medical Engineering Laboratory,
2 Division of Neuropathology, The Jikei University School of Medicine – Tokyo, Japan
3 Faculty of Engineering, The University of Tokyo – Tokyo, Japan
4 Department of Veterinary Medicine, Tokyo University of Agriculture and Technology – Tokyo, Japan
5 Department of Zoology, Faculty of Science, Okayama University of Science – Okayama, Japan
6 Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University – Inuyama, Japan
7 Graduate School of Biomedical Engineering, Tohoku University – Sendai, Japan

Objective: We are developing mid-frequency sonothrombolysis, however, hemorrhagic complication in TRUMBI trial is a fence at these frequency. We evaluated safety in primate with a developed 490 kHz continuous waveform (CW)-US probe and investigated 400 kHz burst waveform (BW)-US emission for rabbit.