• WHICH STUDY DESIGN IS APPROPRIATE FOR SONOTHROMBOLYSIS TRIALS? THE ULTRAS PILOT STUDY

    M. Del Sette 1, S. Ricci 2, E. Giorli 1, M. Cotroneo 3
    1 Neurology Unit – La Spezia, Italy,
    2 Stroke Unit – Città di Castello, Italy,
    3 Department of Neurology University of Messina – Messina, Italy

    Objective: sonothrombolysis (ST) can increase the penetration of circulating tPA into the thrombus, promote the breaking and cleaving of the fibrin polymers, and improve the binding affinity of tPA to fibrin. A recent Cochrane Review of all the randomized studies published on ST reported significantly more recanalizations and better clinical outcome, with no effect on mortality. The ultras study is a pilot study aiming at defining efficacy of ST in acute ischemic stroke.

  • INFLUENCE OF EARLY PHYSICAL THERAPY PROGRAM IN PATIENTS WITH ACUTE ISCHEMIC STROKE

    K. Grigorova-Petrova, D. Lubenova, A. Dimitrova
    National Sports Academy Vassil Levski – Sofia, Bulgaria

    Objective: To study the effect of application of the feedback breathing device and therapeutic exercises on motor deficits and respiratory disorders in patients with ischemic stroke.

    Material and Methods: Ten patients (NIHHS – up to 14 points, Glasgow-Liege scale – 20 points) with acute ischemic stroke were studied. Changes of trunk control (Trunk Kontrol Test), pulmonary function (spirometry), inspiratory capacity (feedback breathing device for inspiratory training) were measured before and after physical therapy program.